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In vitro modelling of anterior primitive streak patterning with human pluripotent stem cells identifies the path to notochord progenitors

29 Nov 2024

Abstract excerpt

Notochord progenitors (NotoPs) represent a scarce yet crucial embryonic cell population, playing important roles in embryo patterning and eventually giving rise to the cells that form and maintain intervertebral discs. The mechanisms regulating NotoPs emergence are unclear. This knowledge gap persists due to the inherent complexity of cell fate patterning during gastrulation, particularly within the anterior...

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PMID: 39611739
DOI: 10.1242/dev.202983

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