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Morphogen dynamics control patterning in a stem cell model of the human embryo

2017-10-13

Abstract excerpt

During embryonic development, diffusible signaling molecules called morphogens are thought to determine cell fates in a concentration-dependent manner 1–4 , and protocols for directed stem cell differentiation are based on this picture 5–8 . However, in the mammalian embryo, morphogen concentrations change rapidly compared to the time for making cell fate decisions 9–12 . It is unknown how changing ligand level...

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Literature Corpus work
2391a75e-28d5-50b3-bf52-6e7087bcc0eb
DOI
10.1101/202366
Open publication

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Morphogen dynamics control patterning in a stem cell model of the human embryoDOI 10.1101/202366
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