Inference and validation of a dynamic gene regulatory network influencing cell fate during Duchenne muscular dystrophy initiation

Abstract excerpt

The onset of gene regulatory disturbances leading to developmental disorders remains poorly understood, particularly when symptoms begin after birth. Using induced pluripotent stem cells, single-cell transcriptomics and computational modeling, we determined the gene expression waves guiding early myogenesis and how they are affected by a disease-causing mutation. We uncovered a dynamic gene regulatory network orga...

Topics

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• Gene Expression
• Gene Regulatory Networks
• Genetics, Population
• Polymorphism, Single Nucleotide
• Quantitative Trait Loci
• RNA-Seq
• Sequence Analysis, RNA
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

5d786eb7-081e-5ab2-aacb-21f87b453a6c

DOI

10.1101/2025.11.19.689189