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Article

Molecular mechanism of symmetry breaking in a 3D model of a human epiblast

2018-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Breaking the anterior-posterior (AP) symmetry in mammals takes place at gastrulation. Much of the signaling network underlying this process has been elucidated in the mouse, however there is no direct molecular evidence of events driving axis formation in humans. Here, we use human embryonic stem cells to generate an in vitro 3D model of a human epiblast whose size, cell polarity, and gene expr...

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Literature Corpus work
059dea93-6c6f-5564-adc6-7850f481ac44
DOI
10.1101/330704
Open publication

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