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Comparison between the activities of canonical Wnt ligands in human pluripotent stem cell differentiation

2025-12-22

Abstract excerpt

WNT ligands are key regulators of mammalian gastrulation and anterior-posterior (A–P) patterning. The activities of different Wnt ligands that signal through the canonical pathway are often assumed to be similar due to their high structural homology. To explore potential differences, we generated human pluripotent stem cell (hPSC) lines with inducible expression of WNT3, WNT3A, WNT6, or WNT8A, enabling direct comp...

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Literature Corpus work
18d2d9b3-c653-54d2-9f48-c5cd4ea59110
DOI
10.64898/2025.12.18.695264
Open publication

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Comparison between the activities of canonical Wnt ligands in human pluripotent stem cell differentiationDOI 10.64898/2025.12.18.695264
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