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Systematic identification of functional SNPs interrupting 3'UTR polyadenylation signals.

PLoS genetics - 1 Aug 2020

Shulman Eldad David, Elkon Ran

Abstract excerpt

Alternative polyadenylation (APA) is emerging as a widespread regulatory layer since the majority of human protein-coding genes contain several polyadenylation (p(A)) sites in their 3'UTRs. By generating isoforms with different 3'UTR length, APA potentially affects mRNA stability, translation efficiency, nuclear export, and cellular localization. Polyadenylation sites are regulated by adjacent RNA cis-regulatory...

Topics

Gene Expression Regulation
Humans
Poly A
Polyadenylation
Polymorphism, Single Nucleotide
RNA 3' Polyadenylation Signals
RNA Stability
RNA, Messenger

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32804959
DOI: 10.1371/journal.pgen.1008977
PMCID: PMC7451987

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