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Article

Female mice with a Xist deletion in B cells can develop lupus-associated phenotypes.

Cell reports - 23 Jun 2026

Lovell Claudia D, Jiwrajka Nikhil, Toothacre Natalie E, Amerman Hayley K, Cancro Michael P, Anguera Montserrat C

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease preferentially observed in women. X-linked gene expression in XX females is equalized with that in XY males by X chromosome inactivation (XCI). However, B cells from female patients with SLE and mouse models of SLE exhibit aberrant X-linked gene expression and mislocalization of Xist RNA, a critical regulator of XCI, suggesting that impaired XCI may...

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Share to Autoantibodies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Lupus Erythematosus, Systemic

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Source

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Identifiers

PMID: 42284143
DOI: 10.1016/j.celrep.2026.117517
PMCID: PMC13349233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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