Article

<i>Xist</i> Deletion in B Cells Results in Systemic Lupus Erythematosus Phenotypes

2024-05-18

Abstract excerpt

<h4>SUMMARY</h4> Systemic lupus erythematosus (SLE) is an autoimmune disease preferentially observed in females. X-linked gene expression in XX females is normalized to that of XY males by X-Chromosome Inactivation (XCI). However, B cells from female SLE patients and mouse models of SLE exhibit mislocalization of Xist RNA, a critical regulator of XCI, and aberrant expression of X-linked genes, suggesting that imp...

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Literature Corpus work: 136292e9-a7a9-501c-bc88-1889d2c6e13d
DOI: 10.1101/2024.05.15.594175

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