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Article

Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles.

Nature communications - 9 May 2022

Bishop Alena L, López Del Amo Víctor, Okamoto Emily M, Bodai Zsolt, Komor Alexis C, Gantz Valentino M

Abstract excerpt

Homing CRISPR gene drives could aid in curbing the spread of vector-borne diseases and controlling crop pest and invasive species populations due to an inheritance rate that surpasses Mendelian laws. However, this technology suffers from resistance alleles formed when the drive-induced DNA break is repaired by error-prone pathways, which creates mutations that disrupt the gRNA recognition sequence and prevent...

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PMID: 35534475
DOI: 10.1038/s41467-022-29868-3
PMCID: PMC9085836

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