Article

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood

2024-12-12

Abstract excerpt

Type 1 Diabetes (T1D) is a T-cell mediated disease with a strong immunogenetic HLA dependence. HLA allelic influence on the T cell receptor (TCR) repertoire shapes thymic selection and controls activation of diabetogenic clones, yet remains largely unresolved in T1D. We sequenced the circulating TCRβ chain repertoire from 2250 HLA-typed individuals across three cross-sectional cohorts, including T1D patients,...

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Literature Corpus work: 727b04e4-88a5-5766-ad3e-83f0e0e68dd6
DOI: 10.1101/2024.12.10.24318751

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