Article

Unbiased discovery of autoreactive type 1 diabetes T-cell receptors that bind specific hybrid insulin peptides

2026-07-14

Abstract excerpt

<title>Abstract</title> <p>While recent studies have revealed much about the pathogenesis of type 1 diabetes (T1D), the self-antigens and immune receptors that drive cellular autoimmunity have not been precisely determined. In this study, we identify disease-associated T-cell receptor (TCR) sequences, provide evidence that they are involved in T1D pathogenesis, and connect them to specific antigens implicated in...

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Literature Corpus work: 3c7d1612-84cd-5573-9ef0-de29532027bb
DOI: 10.21203/rs.3.rs-10074672/v1

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