Article

Genetic association and machine learning improves discovery and prediction of type 1 diabetes

2024-08-02

Abstract excerpt

Type 1 diabetes (T1D) has a large genetic component, and expanded genetic studies of T1D can lead to novel biological and therapeutic discovery and improved risk prediction. In this study, we performed genetic association and fine-mapping analyses in 817,718 European ancestry samples genome-wide and 29,746 samples at the MHC locus, which identified 165 independent risk signals for T1D of which 19 were novel. We us...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4e8a358e-26f9-5f77-b7e0-6ad6331d2bf8
DOI: 10.1101/2024.07.31.24311310

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic association and machine learning improves discovery and prediction of type 1 diabetesDOI 10.1101/2024.07.31.24311310Read

Genetic association and machine learning improve the prediction of type 1 diabetes risk.Semantic proximity Read

Genetic discovery and risk prediction for type 1 diabetes in individuals without high-risk HLA-DR3/DR4 haplotypesSemantic proximity Read

Clinical and research uses of genetic risk scores in type 1 diabetes.Semantic proximity Read

Type 1 Diabetes Genetic Risk Scores: History, Application and Future Directions.Semantic proximity Read

Genetics of type 1 diabetesSemantic proximity Read

Type 1 Diabetes Genetics ConsortiumSemantic proximity Read

Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 HaplotypesSemantic proximity Read

Next steps in the identification of gene targets for type 1 diabetes.Semantic proximity Read

Genetics and its potential to improve type 1 diabetes care.Semantic proximity Read

The past, present, and future of genetic associations in type 1 diabetes.Semantic proximity Read

DRB1 Subtyping Reveals Divergent Risk and Protection for Type 1 Diabetes in Middle Eastern PopulationsSemantic proximity Read

Genetics of Type 1 Diabetes: What's Next?Semantic proximity Read