Article

Autoimmune interactions between the HLA-DQβ1<sub>57</sub>polymorphism, T cell receptors, and microbial mimics of insulin in type 1 diabetes

2022-05-14

Abstract excerpt

Insulin autoimmunity and pancreatic islet β-cell destruction, mediated by T cells, underlie the pathogenesis of type 1 diabetes (T1D). However, the mechanisms by which genetic and environmental risk factors interact to cause T1D remain incompletely understood. Here, we show how variation in the human leukocyte antigen (HLA) class II region, notably DQβ1 57 , the strongest T1D genetic risk factor, induces a positiv...

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Literature Corpus work: 02761737-2f1b-5ce8-b13b-e347a448146b
DOI: 10.1101/2022.05.11.22274678

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