Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas

13 Jun 2024

Abstract excerpt

Human type 1 diabetes (T1D) is caused by autoimmune attack on the insulin-producing pancreatic beta cells by islet antigen-reactive T cells. How human islet antigen-reactive (IAR) CD4+ memory T cells from peripheral blood affect T1D progression in the pancreas is poorly understood. Here, we aim to determine if IAR T cells in blood could be detected in pancreas. We identify paired αβ (TRA/TRB) T cell receptors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Immune Cell Function and Interaction
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38871688
DOI: 10.1038/s41467-024-48833-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreasPMID 38871688Read ↗

Self-reactive germline-like TCR alpha chains shared between blood and pancreasSemantic proximity Read ↗

Tracking DNA-based antigen-specific T cell receptors during progression to type 1 diabetesSemantic proximity Read ↗

The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR ConsortiumSemantic proximity Read ↗

Unbiased discovery of autoreactive type 1 diabetes T-cell receptors that bind specific hybrid insulin peptidesSemantic proximity Read ↗

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral bloodSemantic proximity Read ↗

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood.Semantic proximity Read ↗

Islet-antigen reactive B cells display a unique phenotype and BCR repertoire in autoantibody positive and recent-onset type 1 diabetes patientsSemantic proximity Read ↗

Temporal development of T cell receptor repertoires during childhood in health and diseaseSemantic proximity Read ↗

Using the T Cell Receptor as a Biomarker in Type 1 Diabetes.Semantic proximity Read ↗

Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twinsSemantic proximity Read ↗

High diversity in the TCR repertoire of GAD65 autoantigen-specific human CD4+ T cells.Semantic proximity Read ↗

Autoimmune interactions between the HLA-DQβ1<sub>57</sub>polymorphism, T cell receptors, and microbial mimics of insulin in type 1 diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.