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Temporal development of T cell receptor repertoires during childhood in health and disease

23 Aug 2022

Abstract excerpt

T cell receptor (TCR) sequences are exceptionally diverse and can now be comprehensively measured with next-generation sequencing technologies. However, a thorough investigation of longitudinal TCR repertoires throughout childhood in health and during development of a common childhood disease, type 1 diabetes (T1D), has not been undertaken. Here, we deep sequenced the TCR-β chain repertoires from longitudinal...

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PMID: 35998036
DOI: 10.1172/jci.insight.161885

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