Article

Self-reactive germline-like TCR alpha chains shared between blood and pancreas

2023-10-20

Abstract excerpt

<title>Abstract</title> <p>Human islet antigen reactive CD4 + memory T cells (IAR T cells) from peripheral blood have been studied extensively for their role in the pathogenesis of autoimmune type 1 diabetes (T1D). However, IAR T cells are rare, and it remains poorly understood how they affect T1D progression in the pancreas. Using single cell RNA-sequencing coupled with a multiplexed activation induced marker (A...

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Literature Corpus work: 434f91fd-8798-568a-8758-04f64dba52da
DOI: 10.21203/rs.3.rs-3446917/v1

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