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Tracking DNA-based antigen-specific T cell receptors during progression to type 1 diabetes

8 Dec 2023

Abstract excerpt

T cells targeting self-proteins are important mediators in autoimmune diseases. T cells express unique cell-surface receptors (TCRs) that recognize peptides presented by major histocompatibility molecules. TCRs have been identified from blood and pancreatic islets of individuals with type 1 diabetes (T1D). Here, we tracked ~1700 known antigen-specific TCR sequences, islet antigen or viral reactive, in bulk TCRβ...

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PMID: 38064552
DOI: 10.1126/sciadv.adj6975

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