Article

Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING <sup>A230</sup> Variants

2023-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Previously we identified a non-nucleotide tricyclic agonist BDW568 that activates human STING (stimulator of interferon genes) gene variant containing A230 in a human monocyte cell line (THP-1). STING A230 alleles, including HAQ and AQ, are less common STING variants in human population. To further characterize the mechanism of BDW568, we obtained the crystal structure of the C-terminal domain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7205a772-cf4f-5b1a-a963-144046778cb4
DOI: 10.1101/2023.07.02.547363

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING <sup>A230</sup> VariantsDOI 10.1101/2023.07.02.547363Read

Nitrofuran-Based STING InhibitorsSemantic proximity Read

Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner.Semantic proximity Read

Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effectSemantic proximity Read

Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutationSemantic proximity Read

A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists.Semantic proximity Read

Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes AgonistSemantic proximity Read

The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties.Semantic proximity Read

Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides.Semantic proximity Read

Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligenceSemantic proximity Read

The Many Ways to Deal with STINGSemantic proximity Read

Orthosteric STING inhibition elucidates molecular correction of SAVI STINGSemantic proximity Read

Comparative Molecular, Innate, and Adaptive Impacts of Chemically Diverse STING AgonistsSemantic proximity Read