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Article

Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist

6 May 2019

Abstract excerpt

Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2′3′-cGAMP synthesized by cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms. Pharmacologic activation of STING has been demonstrated to induce an...

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PMID: 31060350
DOI: 10.1021/acsinfecdis.9b00010

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