Article

Comparative Molecular, Innate, and Adaptive Impacts of Chemically Diverse STING Agonists

2025-02-27

Abstract excerpt

<h4>ABSTRACT</h4> Pharmacologic activation of the innate immune response is being actively being pursued for numerous clinical purposes including enhancement of vaccine potency and potentiation of anti-cancer immunotherapy. Pattern recognition receptors (PRRs) represent especially useful targets for these efforts as their engagement by agonists can trigger signaling pathways that associate with phenotypes desirab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eb7428a5-87f3-5599-8f22-77be3b4bd1e7
DOI: 10.1101/2025.02.21.639458

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative Molecular, Innate, and Adaptive Impacts of Chemically Diverse STING AgonistsDOI 10.1101/2025.02.21.639458Read

Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner.Semantic proximity Read

The Many Ways to Deal with STINGSemantic proximity Read

cGAS-STING pathway in cancer biotherapySemantic proximity Read

Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes AgonistSemantic proximity Read

Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effectSemantic proximity Read

IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunitiesSemantic proximity Read

Characterization of a Novel Transmembrane Activating STING Agonist using Genetically Humanized MiceSemantic proximity Read

Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligenceSemantic proximity Read

A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists.Semantic proximity Read

Cytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulumSemantic proximity Read

Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseasesSemantic proximity Read

STING pathway agonism as a cancer therapeuticSemantic proximity Read