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Article

Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides.

PloS one - 1 Jan 2013

Yi Guanghui, Brendel Volker P, Shu Chang, Li Pingwei, Palanathan Satheesh, Cheng Kao C

Abstract excerpt

The STING (stimulator of interferon genes) protein can bind cyclic dinucleotides to activate the production of type I interferons and inflammatory cytokines. The cyclic dinucleotides can be bacterial second messengers c-di-GMP and c-di-AMP, 3'5'-3'5' cyclic GMP-AMP (3'3' cGAMP) produced by Vibrio cholerae and metazoan second messenger 2'5'-3'5' Cyclic GMP-AMP (2'3' cGAMP). Analysis of single nucleotide...

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Identifiers

PMID: 24204993
DOI: 10.1371/journal.pone.0077846
PMCID: PMC3804601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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