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Article

Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

13 Dec 2022

Abstract excerpt

Stimulator of interferon gene (STING) is increasingly exploited for the potential in cancer immunotherapy, yet its mechanism of activation remains not fully understood. Herein, we designed a novel STING agonist, designated as HB3089 that exhibits robust and durable anti-tumor activity in tumor models across various cancer types. Cryo-EM analysis reveals that HB3089-bound human STING has structural changes similar...

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PMID: 36513640
DOI: 10.1038/s41421-022-00481-4

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