Article
Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner.
Frontiers in immunology - 1 Jan 2020
Abraham Jinu, Botto Sara, Mizuno Nobuyo, Pryke Kara, Gall Bryan, Boehm Dylan, Sali Tina M, Jin Haihong, Nilsen Aaron, Gough Michael, Baird Jason, Chakhtoura Marita, Subra Caroline, Trautmann Lydie, Haddad Elias K, DeFilippis Victor R
Abstract excerpt
The innate immune response to cytosolic DNA involves transcriptional activation of type I interferons (IFN-I) and proinflammatory cytokines. This represents the culmination of intracellular signaling pathways that are initiated by pattern recognition receptors that engage DNA and require the adaptor protein Stimulator of Interferon Genes (STING). These responses lead to the generation of cellular and tissue...
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