The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties.

doi:10.1038/s41598-023-46830-5

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The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties.

Scientific reports - 9 Nov 2023

Froechlich Guendalina, Finizio Arianna, Napolano Alessandra, Amiranda Sara, De Chiara Arianna, Pagano Pasqualina, Mallardo Massimo, Leoni Guido, Zambrano Nicola, Sasso Emanuele

Abstract excerpt

Different innate immune pathways converge to Stimulator of interferon genes (STING) and trigger type I interferon responses after recognition of abnormal nucleic acids in the cells. This non-redundant function renders STING a major player in immunosurveillance, and an emerging target for cancer and infectious diseases therapeutics. Beyond somatic mutations that often occur in cancer, the human gene encoding STING...

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The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties.

Abstract excerpt

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