Article

Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence

2022-05-25

Abstract excerpt

The protein STING (stimulator of interferon genes) is a central regulator of the innate immune system and plays an important role in antitumor immunity by inducing the production of cytokines such as type I interferon (IFN). Activation of STING stems from the selective recognition of endogenous cyclic dinucleotides (CDNs) by the large, polar, and flexible binding site, thus posing challenges to the design of small...

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Literature Corpus work: f353eca8-f895-59a5-85dc-ad119851c7b1
DOI: 10.1101/2022.05.23.493001

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