Article

Extruding transcription elongation loops observed in high-resolution single-cell 3D genomes

2023-09-25

Abstract excerpt

<title>Abstract</title> <p>Inside human nuclei, genes are transcribed within a highly packed genome, whose organization is facilitated by cohesin-mediated loop extrusion. However, how cohesin folds transcribed genes and affects transcription remain unclear. Here we report that highly expressed long genes form a “stripe-like” structure termed transcription elongation loop (TEL), which aligns between the transcript...

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Literature Corpus work: c5f48fdb-fb28-57de-b352-f8b59cf8f071
DOI: 10.21203/rs.3.rs-3351341/v1

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