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Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression

29 Sept 2021

Abstract excerpt

Alternative splicing of the gene MAPT produces several isoforms of tau protein. Overexpression of these isoforms is characteristic of tauopathies, which are currently untreatable neurodegenerative diseases. Though non-canonical functions of tau have drawn interest, the role of tau isoforms in these diseases has not been fully examined and may reveal new details of tau-driven pathology. In particular, tau has been...

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PMID: 34587152
DOI: 10.1371/journal.pone.0251611

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