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Widespread transposable element dysregulation in human aging brains with Alzheimer's disease

2 Oct 2024

Abstract excerpt

INTRODUCTION: Transposable element (TE) dysregulation is associated with neuroinflammation in Alzheimer's disease (AD) brains. Yet, TE quantitative trait loci (teQTL) have not been well characterized in human aged brains with AD. METHODS: We leveraged large-scale bulk and single-cell RNA sequencing, whole-genome sequencing (WGS), and xQTL from three human AD brain biobanks to characterize TE expression...

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PMID: 39356058
DOI: 10.1002/alz.14164

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