Article

Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression

2021-04-30

Abstract excerpt

Alternative splicing of the gene MAPT produces several isoforms of tau protein. Overexpression of these isoforms is characteristic of tauopathies, which are currently untreatable neurodegenerative diseases. Though non-canonical functions of tau have drawn interest, the role of tau isoforms in these diseases has not been fully examined and may reveal new details of tau-driven pathology. In particular, tau has been...

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Literature Corpus work: d42a6eb6-8867-5f9d-ae8e-81e21b83f349
DOI: 10.1101/2021.04.30.442101

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