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Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model

2024-02-04

Abstract excerpt

Missense mutations in the gene encoding the microtubule-associated protein tau cause autosomal dominant forms of frontotemporal dementia. Multiple models of frontotemporal dementia based on transgenic expression of human tau in experimental model organisms, including Drosophila , have been described. These models replicate key features of the human disease, but do not faithfully recreate the genetic context of th...

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Literature Corpus work: a3d2a10d-8082-53ef-863a-a4769d9813de
DOI: 10.1101/2024.02.02.578624

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Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a <i>Drosophila</i> knock-in tauopathy model

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