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Centenarian SIRT6 variants elevate SIRT6 protein and enhance cellular senescence resistance

2026-06-19

Abstract excerpt

<title>Abstract</title> <p> Centenarians represent a natural model of delayed human aging, offering a unique opportunity to uncover genetic mechanisms that promote longevity. However, the functional consequences of the genetics variants carried by these long-lived individuals remain poorly characterized in physiologically relevant systems. Here, we introduced two linked missense variants in <italic>SIRT6</itali...

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Identifiers and source

Literature Corpus work
71e6b49c-03f7-588f-9aff-2c6cd36d9438
DOI
10.21203/rs.3.rs-9997679/v1
Open publication

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