Article

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

2021-12-13

Abstract excerpt

<h4>SUMMARY</h4> Sirtuin 6 (SIRT6) is a deacylase and mono-ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in the regulation of aging and metabolism. Targeted sequencing identified a SIRT6 allele containing two linked substitutions (N308K/A313S) as enriched in Ashkenazi Jewish (AJ) centenarians as compared to AJ control individuals. Characterization of this SIRT6 (centSIRT...

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Literature Corpus work: 57812934-c2d5-50dd-bc79-40a0f0e0bfc3
DOI: 10.1101/2021.12.13.472381

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