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Article

Rare centenarian SIRT6 variants elevate SIRT6 protein levels and resist cellular senescence

2025-09-30

Abstract excerpt

Centenarians provide valuable insights into the biological mechanisms underlying human longevity and potential gerotherapeutic targets. We previously identified two linked missense variants in SIRT6 that are enriched in Ashkenazi Jewish centenarians. To investigate their functional impact in physiologically relevant cellular contexts, we generated human embryonic stem cells carrying these variants through precise...

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Identifiers and source

Literature Corpus work
341c795d-6a0b-57a6-b5df-03c35231e62d
DOI
10.1101/2025.09.29.679208
Open publication

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Rare centenarian SIRT6 variants elevate SIRT6 protein levels and resist cellular senescenceDOI 10.1101/2025.09.29.679208
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