Article
Assignment of the NAD-dependent deacetylase sirtuin 5 gene <i>(SIRT5)</i> to human chromosome band 6p23 by in situ hybridization
1 Jan 2006
Abstract excerpt
Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase and belongs to the Silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (HDACs), which play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging. We have isolated and characterized the human SIRT5 genomic sequence,...
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