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Article

Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant.

Clinical epigenetics - 20 Jul 2024

Frohlich Jan, Liorni Niccolò, Mangoni Manuel, Lochmanová Gabriela, Pírek Pavlína, Kaštánková Nikola, Pata Pille, Kucera Jan, Chaldakov George N, Tonchev Anton B, Pata Illar, Gorbunova Vera, Leire Eric, Zdráhal Zbyněk, Mazza Tommaso, Vinciguerra Manlio

Abstract excerpt

BACKGROUND: Obesity is a major health burden. Preadipocytes proliferate and differentiate in mature adipocytes in the adipogenic process, which could be a potential therapeutic approach for obesity. Deficiency of SIRT6, a stress-responsive protein deacetylase and mono-ADP ribosyltransferase enzyme, blocks adipogenesis. Mutants of SIRT6 (N308K/A313S) were recently linked to the in the long lifespan Ashkenazi Jews....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39033117
DOI: 10.1186/s13148-024-01710-1
PMCID: PMC11265064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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