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Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress

2026-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Sirtuin 6 (SIRT6) is a protein deacetylase and ribosyltransferase that is a vital hub for maintaining epigenetic homeostasis, regulating the transcriptome, and repairing DNA double stranded breaks (DSBs). Comprehensive proteomic profiling of the SIRT6 post-translational landscape, however, remains elusive. The SIRT6 C-terminal domain contains multiple phosphorylation sites. We find that the pres...

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Identifiers and source

Literature Corpus work
9f85dab7-a404-5314-a9b6-f36caea074d2
DOI
10.64898/2026.04.22.718469
Open publication

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Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stressDOI 10.64898/2026.04.22.718469
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