Article
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A.
The EMBO journal - 2 Nov 2022
Simon Matthew, Yang Jiping, Gigas Jonathan, Earley Eric J, Hillpot Eric, Zhang Lei, Zagorulya Maria, Tombline Greg, Gilbert Michael, Yuen Samantha L, Pope Alexis, Van Meter Michael, Emmrich Stephan, Firsanov Denis, Athreya Advait, Biashad Seyed Ali, Han Jeehae, Ryu Seungjin, Tare Archana, Zhu Yizhou, Hudgins Adam, Atzmon Gil, Barzilai Nir, Wolfe Aaron, Moody Kelsey, Garcia Benjamin A, Thomas David D, Robbins Paul D, Vijg Jan, Seluanov Andrei, Suh Yousin, Gorbunova Vera
Abstract excerpt
Sirtuin 6 (SIRT6) is a deacylase and mono-ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in aging and metabolism regulation. Targeted sequencing of SIRT6 locus in a population of 450 Ashkenazi Jewish (AJ) centenarians and 550 AJ individuals without a family history of exceptional longevity identified enrichment of a SIRT6 allele containing two linked substitutions...
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