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Sirtuins and DNA damage repair: SIRT7 comes to play

17 Feb 2017

Abstract excerpt

Aging is characterized by a cumulative loss of genome integrity, which involves chromatin reorganization, transcriptional dysregulation and the accumulation of DNA damage. Sirtuins participate in the protection against these aging processes by promoting genome homeostasis in response to cellular stress. We recently reported that SirT7−/− mice suffer from partial embryonic lethality and a progeroid like phenotype....

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PMID: 28406750
DOI: 10.1080/19491034.2016.1264552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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