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Article

The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells

8 May 2013

Abstract excerpt

Aging is known to be the single most important risk factor for multiple diseases. Sirtuin 6, or SIRT6, has recently been identified as a critical regulator of transcription, genome stability, telomere integrity, DNA repair, and metabolic homeostasis. A knockout mouse model of SIRT6 has displayed dramatic phenotypes of accelerated aging. In keeping with its role in aging, we demonstrated that human dermal...

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PMID: 23653361
DOI: 10.1074/jbc.m112.405928

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