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Article

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

15 Jan 2016

Abstract excerpt

SIRT6 belongs to the mammalian homologs of Sir2 histone NAD(+)-dependent deacylase family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal tissues. It remains unknown whether human SIRT6 has a direct role in maintaining the homeostasis of mesodermal tissues. To this end, we generated SIRT6 knockout human mesenchymal stem cells (hMSCs) by targeted gene editing. SIRT6-deficient...

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PMID: 26768768
DOI: 10.1038/cr.2016.4

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