Article

Cardelino: Integrating whole exomes and single-cell transcriptomes to reveal phenotypic impact of somatic variants

2018-09-10

Abstract excerpt

Decoding the clonal substructures of somatic tissues sheds light on cell growth, development and differentiation in health, ageing and disease. DNA-sequencing, either using bulk or using single-cell assays, has enabled the reconstruction of clonal trees from frequency and co-occurrence patterns of somatic variants. However, approaches to systematically characterize phenotypic and functional variations between indi...

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Literature Corpus work: bc7a0d4a-8b21-5fa1-ae21-eae841882b91
DOI: 10.1101/413047

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