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Measures of genetic diversification in somatic tissues at bulk and single-cell resolution

18 Sept 2023

Abstract excerpt

Intra-tissue genetic heterogeneity is universal to both healthy and cancerous tissues. It emerges from the stochastic accumulation of somatic mutations throughout development and homeostasis. By combining population genetics theory and genomic information, genetic heterogeneity can be exploited to infer tissue organization and dynamics in vivo. However, many basic quantities, for example the dynamics of...

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PMID: 38265286
DOI: 10.7554/elife.89780

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