Article

Trans- and cis-acting effects of the lncRNA <i>Firre</i> on epigenetic and structural features of the inactive X chromosome

2019-06-30

Abstract excerpt

Firre encodes a lncRNA involved in nuclear organization in mammals. Here we find that Firre RNA is transcribed from the active X chromosome (Xa) and exerts trans-acting effects on the inactive X chromosome (Xi). Allelic deletion of Firre on the Xa in a mouse hybrid fibroblast cell line results in a dramatic loss of the histone modification H3K27me3 and of components of the PRC2 complex on the Xi as well as the d...

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Literature Corpus work: 71c40de9-be12-5808-b759-23cd5d274b65
DOI: 10.1101/687236

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