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Article

Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome.

Nature communications - 27 Nov 2020

Fang He, Bonora Giancarlo, Lewandowski Jordan P, Thakur Jitendra, Filippova Galina N, Henikoff Steven, Shendure Jay, Duan Zhijun, Rinn John L, Deng Xinxian, Noble William S, Disteche Christine M

Abstract excerpt

Firre encodes a lncRNA involved in nuclear organization. Here, we show that Firre RNA expressed from the active X chromosome maintains histone H3K27me3 enrichment on the inactive X chromosome (Xi) in somatic cells. This trans-acting effect involves SUZ12, reflecting interactions between Firre RNA and components of the Polycomb repressive complexes. Without Firre RNA, H3K27me3 decreases on the Xi and...

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Identifiers

PMID: 33247132
DOI: 10.1038/s41467-020-19879-3
PMCID: PMC7695720

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