Article
X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes.
Nature communications - 5 Dec 2024
Hasenbein Tim P, Hoelzl Sarah, Smith Zachary D, Gerhardinger Chiara, Gonner Marion O C, Aguilar-Pimentel Antonio, Amarie Oana V, Becker Lore, Calzada-Wack Julia, Dragano Nathalia R V, da Silva-Buttkus Patricia, Garrett Lillian, Hölter Sabine M, Kraiger Markus, Östereicher Manuela A, Rathkolb Birgit, Sanz-Moreno Adrián, Spielmann Nadine, Wurst Wolfgang, Gailus-Durner Valerie, Fuchs Helmut, Hrabě de Angelis Martin, Meissner Alexander, Engelhardt Stefan, Rinn John L, Andergassen Daniel
Abstract excerpt
The lncRNA Crossfirre was identified as an imprinted X-linked gene, and is transcribed antisense to the trans-acting lncRNA Firre. The Firre locus forms an inactive-X-specific interaction with Dxz4, both loci providing the platform for the largest conserved chromatin structures. Here, we characterize the epigenetic profile of these loci, revealing them as the most female-specific accessible regions genome-wide....
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