Article

Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells

2019-11-14

Abstract excerpt

<h4>SUMMARY</h4> G-protein-coupled-receptors (GPCRs) modulate insulin secretion from β cells and glucagon secretion from α cells. Here, we developed an integrated approach to study the function of primary human islet cells using genetically modified pseudoislets that resemble native islets across multiple parameters. We studied the G i and G q GPCR pathways by expressing the designer receptors exclusively activ...

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Literature Corpus work: 71bd47e5-a784-5fa4-86e4-39762a9b03e8
DOI: 10.1101/842989

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