Article

Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

2022-11-28

Abstract excerpt

Pancreatic α-cells secrete glucagon, an insulin counter-regulatory peptide hormone critical for the maintenance of glucose homeostasis. Investigation of the function of human α-cells remains a challenge due to the lack of cost-effective purification methods to isolate high-quality α-cells from islets. Here, we use the reaction-based probe diacetylated Zinpyr1 (DA-ZP1) to introduce a novel and simple method for enr...

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Literature Corpus work: dd3f6942-bb24-5e59-8aa2-4c6363c1f9ba
DOI: 10.1101/2022.11.27.518097

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