Article

Cyborg islets: implanted flexible electronics reveal principles of human islet electrical maturation

2024-03-20

Abstract excerpt

Flexible electronics implanted during tissue formation enable chronic studies of tissue-wide electrophysiology. Here, we integrate tissue-like stretchable electronics during organogenesis of human stem cell-derived pancreatic islets, stably tracing single-cell extracellular spike bursting dynamics over months of functional maturation. Adapting spike sorting methods from neural studies reveals maturation-dependent...

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Literature Corpus work: 0ea2daba-ef56-58ba-a0af-3eb605375d7e
DOI: 10.1101/2024.03.18.585551

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