Article

Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen

2021-11-05

Abstract excerpt

<h4>Summary</h4> The mammalian circadian clock drives daily oscillations in physiology and behavior through an autoregulatory transcription feedback loop present in central and peripheral cells. Ablation of the core clock within the endocrine pancreas of adult animals impairs the transcription and splicing of genes involved in hormone exocytosis and causes hypoinsulinemic diabetes. However, identification of drug...

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Literature Corpus work: 58ff6e00-35f9-5f72-a01b-972471db7089
DOI: 10.1101/2021.11.05.467499

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