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A comparative analysis of human and mouse islet G-protein coupled receptor expression

19 Apr 2017

Abstract excerpt

Abstract G-protein coupled receptors (GPCRs) are essential for islet function, but most studies use rodent islets due to limited human islet availability. We have systematically compared the GPCR mRNA expression in human and mouse islets to determine to what extent mouse islets can be used as surrogates for human islets to study islet GPCR function, and we have identified species-specific expression of several...

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PMID: 28422162
DOI: 10.1038/srep46600

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